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Mesotherapy for Facial Rejuvenation

This document has been prepared to help provide you with information about mesotherapy for facial rejuvenation, its risks, and alternative treatments. It is important that you read this information carefully and completely.


Mesotherapy was developed by Dr Michel Pistor in France in 1950. Until a few years ago it was practised primarily in France, South America and Spain. It has gained an importance in recent years as some treatments can also be used in aesthetic medicine to benefit the skin.

Mesotherapy is a medical specialty that involves injecting microscopic quantities of natural extracts, homeopathic agents, pharmaceuticals and vitamins into the skin. It can be used to eliminate cellulite, promote weight loss, treat ageing and sagging skin, and rejuvenate the hands and neck.

This is a cosmetic procedure and will not be covered by your medical aid.

Explanation /Procedure

Mesotherapy is a recognized medical treatment for various pathologies and also including aesthetic medicine. The concept of facial rejuvenation mesotherapy is based on nourishing and stimulating the healing cascade for collagen and elastic synthesis. Mesotherapy is a treatment involving injections of medications, amino acids, vitamins, minerals, and homeopathics just under the skin using short needles and specific injection techniques.


Superficial nappage - superficial injections to the epidermal layer (1mm depth).

Superficial intradermal- multiple papules (2mm depth) made to the intrabasal layer.

Deep intra-dermal - point-by-point injections (4- 10 mm depth).

Nappage is the most commonly used technique and is carried out with a multi-pricking technique. It is described as a technique where 2 – 4 injections are made per second, every 2-4 mm apart at an angle of 30 – 60 degrees from the skin surface. The needle penetrates to a depth of 2 – 4 mm while constant unchanging pressure is applied to the piston of the syringe. Nappage involves using a 30G 4 mm needle and a syringe of 3 – 10 ml.

Advantages include significant cutaneous stimulation and ability to cover large surface areas. It is associated with minimal pain and it has a rapid action.

Mechanism of action

Mechanism of action in mesotherapy is a combination of multiple injection points stimulating the body’s natural healing cascade for rejuvenation results and also that of the ingredients, amino acids and vitamins being injected.

  • 12 vitamins - A, B, C and D stimulates vital cell functions
  • 23 amino acids - promotes elastin and collagen production
  • 6 coenzymes - catalyses biochemical reactions between cells
  • 5 nucleic acid - bases facilitates and promotes cellular communications
  • 6 minerals - prevents and acts on skin deficiencies
  • 1 anti-oxidant - captures free radicals
  • HYALURONIC ACID - helps hydrate and add volume to the skin

Post Care Instructions

Patient can experience some redness, which should resolve within 24 hours. There is no down time and patients can continue with normal skin care regime after 48 hours.

Bruising is common if delicate or sensitive areas are to be treated but this will resolve within 7 – 10 days. Scabs from wound healing should not be picked or removed, as it can result in pigmentation or scarring.

If the patient experiences any side effects other than above mentioned, they should contact NoviSkin immediately on 012 460 4646/50.

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